ABSTRACT
This article presents an analysis of available scientific data on the morphology and nanostructure of the COVID-19 coronavirus. Possible mechanisms of influence of nanosilver particles on the coronavirus are considered. Models of nanosilver complexes with spike protein of coronavirus amino acids were constructed using computer quantum-chemical modeling. The values of electron density distribution, highest occupied molecular orbital, lowest unoccupied molecular orbital, and electron density distribution gradient for each constructed model are obtained. As a result of quantum chemical modeling, it was found that silver nanoparticles can interact with the following amino acids: Proline, glutamine, lysine, arginine, asparagine, histidine, glutamic and aspartic acids, tryptophan, and cysteine, which is due to the presence of additional -NH2, -NH, -SH and -COOH groups in these amino acids that are not involved in the formation of a peptide bond. The freedom of additional groups makes it possible to interact with nanosilver. Analysis of the obtained data showed that the most energy-efficient interaction is the formation of the "tryptophan-nanosilver" complex (E= - 5856.83 kcal/mol). Based on the findings of quantum chemical calculations, the most stable complex is the "cysteine- nanosilver" (Delta E = 0.16 a.u). Copyright (C) 2013 - All Rights Reserved - Pharmacophore
ABSTRACT
The study of the etiology of acute respiratory infections in 4022 hospitalized children aged 1 month to 14 years revealed the involvement of coronavirus in 12.4% of cases (500 children) more often in combination with other pathogens. In the case of coronavirus infection, moderate forms of the infectious process prevail mainly in the form of rhino-pharyngo-tracheitis against the background of subfebrile and febrile temperatures with moderate symptoms of intoxication. Majority of the children had dyspeptic symptoms. Every third child may have a lower respiratory tract lesion (bronchitis, pneumonia). Copyright (c) 2013 - All Rights Reserved - Pharmacophore